The De Novo Formation Of A Gene A Random Mutation Leads To The

The De Novo Formation Of A Gene A Random Mutation Leads To The Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD) In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and RNA modulates transcription factor binding to DNA, though the subsequent effect on transcription remains unclear The study demonstrates that the binding of transcription factor ERα is stabilized at

De Novo Mutations Reflect Development And Aging Of The Human Germline