Targeting Pin1 Exerts Potent Antitumor Activity In Pancreatic Ductal

Targeting Pin1 Exerts Potent Antitumor Activity In Pancreatic Ductal The human prolyl isomerase pin1, best known for its association with carcinogenesis, has recently been indicated in the disease of pancreatic ductal adenocarcinoma (pdac). however, the functions of pin1 and the feasibility of targeting pin1 in pdac remain elusive. for this purpose, we examined the e …. 3.5 pin1 chemical inhibitor all trans retinoic acid exerts potent anticancer activity against pancreatic ductal adenocarcinoma in vivo regarding targeting, pin1 with chemical inhibitor atra has received noticeable results in vitro; we thus examined the functions of atra in vivo.

Targeting Pin1 Exerts Potent Antitumor Activity In Pancreatic Ductal 1. introduction. pancreatic ductal adenocarcinoma (pdac) is a devastating disease and is the fourth leading cause of cancer‐associated mortality. 1 the difference between the incidence and the death rate is still small due to its early distant spread and the lack of efficacious current therapies. 2, 3 whole exome and genome sequencing have identified pdac as a disease of high genetic. The functional roles of pin1 in pdac were explored in vitro and in vivo using both genetic and chemical pin1 inhibition. we showed that pin1 was upregulated in pancreatic cancer and metastatic tissues. high pin1 expression is significantly association with poor clinicopathological features and shorter overall survival and disease‐free survival. Genetic and chemical pin1 ablation showed dramatic inhibition of the tumorigenesis and metastatic spread and then reduced the tumor burden in vivo, providing further evidence for the use of pin1 as a promising therapeutic target in pdac. the human prolyl isomerase pin1, best known for its association with carcinogenesis, has recently been indicated in the disease of pancreatic ductal. Pdf | human prolyl isomerase pin1, best known for its association with carcinogenesis, has recently been indicated in the disease of pancreatic ductal | find, read and cite all the research you.