Synaptic Plasticity One Step At A Time Trends In Neurosciences Striatal enriched tyrosine phosphatase (step) has recently been identified as a crucial player in the regulation of synaptic function. it is restricted to neurons within the cns and acts by downregulating the activity of map kinases, the tyrosine kinase fyn and nmda receptors. by modulating these substrates, step acts on several parallel pathways that impact upon the progression of synaptic. Recently, a series of in vivo investigations directly tested the hypothesis that step is involved in regulating synaptic plasticity [37]. erk activation is required for the consolidation of many forms of long term memory, including fear conditioning [38]. mutations of ptps in their catalytic domain create inactive variants that can be used as.
Synaptic Plasticity One Step At A Time Trends In Neurosciences Striatal enriched tyrosine phosphatase (step) has recently been identified as a crucial player in the regulation of synaptic function. it is restricted to neurons within the cns and acts by downregulating the activity of map kinases, the tyrosine kinase fyn and nmda receptors. by modulating these substrates, step acts on several parallel. One of these ptps was named step (for striatal enriched tyrosine phosphatase, also known as ptpn5), and recent evidence suggests it plays an important role in synaptic plasticity. the past decade has seen considerable advances in our understanding of the function of step, as well as the identification of several target proteins by which step. Synaptic plasticity: one step at a time steven p. braithwaite1, surojit paul2, angus c. nairn3 and paul j. lombroso4 1agy therapeutics inc., 270 e. grand avenue, south san francisco, ca 94080, usa 2department of neurology, university of new mexico, albuquerque, nm 87131, usa. Synaptic plasticity: one step at a time. trends in neurosciences 29(8):452 8; a vast number of studies in neurosciences have been dedicated toward understanding the mechanisms and.
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