Releasing The Brake On Protein Synthesis In Hematopoietic Stem Cells Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. in this issue of cell stem cell, lv et al. (2021) describe a mechanism by which hscs fine tune translation rates by controlling 60s and 40s ribosomal subunit joining through targeted degradation of znf622 in response to stress. Hematopoietic expansion. ribosome biogenesis initiates with rdna transcription and processing of the 40s and 60s subunits in nucleoli.the final maturation of the 60s requires association of late ribosomal proteinsincluding rpl24in the cytoplasm as well as dissociation of the translation initiation factor eif6.
A Protein Synthesis Brake For Hematopoietic Stem Cell Maintenanc Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. in this issue of cell stem cell, lv et al. (2021) describe a. Hematopoietic stem cells (hscs) exhibit a low protein synthesis rate to maintain their stemness ( signer et al. 2014 ). multiple intrinsic mechanisms orchestrate this elaborate process within stem cells, including ribosome biogenesis and assembly, rna modifications, the ubiquitin–proteasome system, and other post translational modifications. Semantic scholar extracted view of "releasing the brake on protein synthesis in hematopoietic stem cells." by craig m. forester et al. Forester cm, ruggero d. releasing the brake on protein synthesis in hematopoietic stem cells. cell stem cell. 2021 jul 01; 28(7):1183 1185.
Hectd1 Controls Hematopoietic Stem Cell Regeneration By Coordinating Semantic scholar extracted view of "releasing the brake on protein synthesis in hematopoietic stem cells." by craig m. forester et al. Forester cm, ruggero d. releasing the brake on protein synthesis in hematopoietic stem cells. cell stem cell. 2021 jul 01; 28(7):1183 1185. Hematopoietic stem cell maintenance and function (tah masebietal.2019;chuaandsigner2020).hematopoietic stem cells (hscs) exhibit a low protein synthesis rate to maintain their stemness (signer et al. 2014). multiple in trinsic mechanisms orchestrate this elaborate process within stem cells, including ribosome biogenesis and. Assembly and protein synthesis in hematopoietic stem cell regeneration. depletionofane3ligase,hectd1,impairs ribosomal subunit joining and protein translation efficiency by promoting retention of its substrate znf622 in regenerating hematopoietic stem cells during stress. lv et al., 2021, cell stem cell 28, 1275–1290 july 1, 2021 ª 2021.
Pdf A Protein Synthesis Brake For Hematopoietic Stem Cell Maint Hematopoietic stem cell maintenance and function (tah masebietal.2019;chuaandsigner2020).hematopoietic stem cells (hscs) exhibit a low protein synthesis rate to maintain their stemness (signer et al. 2014). multiple in trinsic mechanisms orchestrate this elaborate process within stem cells, including ribosome biogenesis and. Assembly and protein synthesis in hematopoietic stem cell regeneration. depletionofane3ligase,hectd1,impairs ribosomal subunit joining and protein translation efficiency by promoting retention of its substrate znf622 in regenerating hematopoietic stem cells during stress. lv et al., 2021, cell stem cell 28, 1275–1290 july 1, 2021 ª 2021.
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